Metabolism Ketamine is metabolized through N-dealkylation on the Energetic metabolite norketamine largely by CYP2B6 and CYP3A4 and also to a lesser extent by other CYP enzymes. Norketamine undergoes hydroxylation with the cyclohexone ring to variety hydroxynorketamine compounds by using CYP-dependent pathways, which are conjugated with glucuronic a